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Effect of Phyllanthus maderaspatensis L. crude methanolic extract on diet induced hypercholesterolemia in Wistar albino rats (Mus norvegicus albinus)

Authors:

D. M. L. C. Dissanayaka,

The Open University of Sri Lanka, Nawala, LK
About D. M. L. C.
Department of Botany, Faculty of Natural Sciences
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N. Nilakarawasam,

The Open University of Sri Lanka, Nawala, LK
About N.
Department of Zoology, Faculty of Natural Sciences
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S. Somaratne,

The Open University of Sri Lanka, Nawala, LK
About S.
Department of Botany, Faculty of Natural Sciences
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S. R. Weerakoon ,

The Open University of Sri Lanka, Nawala, LK
About S. R.
Department of Botany, Faculty of Natural Sciences
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C. Ranasinghe

The Open University of Sri Lanka, Nawala, LK
About C.
Department of Chemistry, Faculty of Natural Sciences
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Abstract

Present experiment was aimed to assess the diet induced hypocholesterolemic activity of crude methanolic extracts of Phyllanthus maderaspatensis L. on Wistar rats. The crude whole plant methanolic extract was administered orally at the dosage of 2000 mg/kg body weight per day, to diet induced hypercholesterolemic Wistar albino rats for 14 days to assess the acute toxicity and hypercholesterolemic activity. Lower concentrations were used since no toxicity found during the acute toxicity experiment. Dosages of Methanolic extracts of 400mg, 800 mg and 1200 mg/ kg body weight per day were orally administered to rats for 42 days whilst total cholesterol, triglyceride, were studied. Hardly any acute toxicity signs and liver toxicity were observed with the extract of 2000 mg/kg. The same concentration indicated a reduction of total cholesterol and triglyceride during 14 days. The groups treated with three lower doses of extract exhibited dose dependent negative response with total cholesterol and triglyceride. Results indicated capability of the crude methanolic extract of P. maderaspatensis L. in total cholesterol and triglyceride in diet induced hypercholestrolemic Wistar rats.
How to Cite: Dissanayaka, D. M. L. C., Nilakarawasam, N., Somaratne, S., Weerakoon, S. R., & Ranasinghe, C. (2019). Effect of Phyllanthus maderaspatensis L. crude methanolic extract on diet induced hypercholesterolemia in Wistar albino rats (Mus norvegicus albinus). Ceylon Journal of Science, 48(3), 285–291. DOI: http://doi.org/10.4038/cjs.v48i3.7653
Published on 16 Sep 2019.
Peer Reviewed

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