Start Submission Become a Reviewer

Reading: Haematological and biochemical changes associated with male rats deprived of feed and water

Download

A- A+
Alt. Display

Research Articles

Haematological and biochemical changes associated with male rats deprived of feed and water

Authors:

B. S. Okediran ,

University of Ilorin, Ilorin, NG
About B. S.
Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine
X close

S. A. Amid,

University of Ilorin, Ilorin, NG
About S. A.
Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine,
X close

F. Sanusi,

University of Ilorin, Ilorin, NG
About F.
Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine
X close

K. O. Oladesu

University of Ilorin, Ilorin, NG
About K. O.
Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine
X close

Abstract

Overnight food and water restriction protocols are common in animal research, however information about the haematological and biochemical changes due to food and water deprivation over longer periods can provide information about the stress experience by these animals. This study was conducted using ten (n = 10) male albino rats housed in metallic cage. The rats were deprived of feed and water consecutively for six days. On the third and sixth days blood samples were obtained for haematological studies while serum was used for biochemical studies. There were significant increases in red cell counts, packed cell volume, haemoglobin concentration and mean corpuscular volume while significant decreases were observed in the mean corpuscular haemoglobin and mean corpuscular haemoglobin concentration as compared to the basal parameters. The white blood cells, neutrophils, eosinophils, monocytes and lymphocytes were significantly increased as compared with the basal parameters. Activities of aspartate and alanine aminotransferase in post feed and water deprivation condition are elevated compared to basal parameters. There were significant decreases in serum glucose, triglyceride, cholesterol concentrations while the total protein, albumin, creatinine, blood urea were significantly elevated. It can be concluded that rats deprived of feed and water predisposes to starvation, dehydration and stress with perturbation of haematological and biochemical parameters.
How to Cite: Okediran, B. S., Amid, S. A., Sanusi, F., & Oladesu, K. O. (2021). Haematological and biochemical changes associated with male rats deprived of feed and water. Ceylon Journal of Science, 50(1), 11–16. DOI: http://doi.org/10.4038/cjs.v50i1.7842
Published on 15 Mar 2021.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus